Fluorine-containing benzoylguanidines

US5747539A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Manfred Baumgarth
• Rolf Gericke · Seeheim-Jugenheim, DE
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: May 15, 1996
• Grant date: May 5, 1998
• Expiry date: May 15, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C279/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fluorine-containing benzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated, and their physiologically acceptable salts, have antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter, for example.