Blockade of neuronal m-channels as a therapeutic approach to the treatment of neurological disease

US5750528A · kind A · utility

Assignee

• The DuPont Merck Pharmaceutical Company · US

Inventors

• Barry Brown · Sussex, US
• Simon Piers Aiken · Wilmington, US
• Robert Zaczek · Avondale, US
• Paul R. Hartig · Mahwah, US
• Christopher A. Teleha · Fort Washington, US
• Wendell W. Wilkerson · New Castle, US
• Richard A. Earl · Wilmington, US

Key dates

• Filing date: Feb 1, 1995
• Grant date: May 12, 1998
• Expiry date: Feb 1, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/498
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds which block neuronal M-channels are useful for treating conditions involving neurotransmitter deficiencies, traumatic brain injury, or the depressive phase of bipolar disorder. Compounds can be evaluated for utility in treating these conditions by determining whether they are capable of blocking neuronal M-channels.