Pyrimidine derivatives and processes for the preparation thereof
US5750531A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1997 |
| Grant date | May 12, 1998 |
| Priority date | — |
| Expiry date | Jan 23, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel pyrimidine derivatives of the formulae (I-1) and (I-2) and pharmaceutically acceptable salts thereof which possess an excellent anti-secretory activity, pharmaceutical compositions containing same as an active ingredient, their novel intermediates, and processes for the preparation thereof: ##STR1## wherein: R.sub.4 and R.sub.5, which may be the same or different, are independently hydrogen or a C.sub.1 -C.sub.3 alkyl group, or jointly form a cyclopentyl or cyclohexyl ring; PA1 A is a group of formula(II): ##STR2## wherein R.sub.1 and R.sub.2 are, independently of each other, hydrogen or a C.sub.1 -C.sub.3 alkyl group, and R.sub.3 is hydrogen, a C.sub.1 -C.sub.3 alkyl group or a halogen; and PA1 B is 1-(substituted)-1,2,3,4-tetrahydroisoquinolin-2-yl of formula (III-1) or 7-(substituted)-4,5,6,7-tetrahydrothieno2,3-c!pyridin-6-yl of formula (III-2) ##STR3## wherein R.sub.6 is hydrogen or a C.sub.1 -C.sub.3 alkyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.