Optionally substituted phenylimidazolidines, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them
US5750553A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 1996 |
| Grant date | May 12, 1998 |
| Priority date | — |
| Expiry date | Jun 27, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula ##STR1## wherein Y is --O--, Z.sub.2 is --CF.sub.3, Z.sub.1 is --CN or --NO.sub.2, X is --O-- or --S--, R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or --CN and R.sub.4 and R.sub.5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, --OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or --OH, and wherein at least one of R.sub.4 and R.sub.5 is substituted having antiandrogenic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.