Bis-indolyl maleinimide or indolopyrrolo carbazole containing an amino acid as PKC inhibitors

US5750555A · kind A · utility

Assignee

• Goedecke GmbH · DE

Inventors

• Uwe Trostmann · Gundelfingen, DE
• Christoph Schachtele · Glückstadt, DE
• Johannes Hartenstein · Kirchzarten, DE
• Claus Rudolph · Denzlingen, DE
• Hubert Barth · Emmendingen, DE
• Reinhard Reck · Waldkirch, DE
• Walter Kolch · Munich, DE

Key dates

• Filing date: Nov 15, 1996
• Grant date: May 12, 1998
• Expiry date: Nov 15, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention is a compound of formula EQU A--X--Y--E.sub.n --R.sup.5 in which A is a bis-indolylmaleinimide or indolopyrrolocarbazole useful in the treatment and/or prevention of cancer, viral diseases, thrombosis, heart rhythm disturbances, atherosclerosis, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system, psoriasis, and immune suppression. A pharmaceutical composition and methods of preparing the compounds are also included.