Bradykinin analogs with non-peptide bond

US5750646A · kind A · utility

Assignees

• The Administrators of the Tulane Educational Fund · US
• Biomeasure, Incorporated · US

Inventors

• David H. Coy · New Orleans, US
• Jacques-Pierre Moreau · Upton, US
• John E. Taylor · Upton, US
• Sun H. Kim · Needham, US

Key dates

• Filing date: Mar 22, 1995
• Grant date: May 12, 1998
• Expiry date: Mar 22, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A linear peptide which is an analog of a naturally occurring, biologically active peptide having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell, cleavage of a peptide bond in the active site to the naturally occurring peptide being unnecessary for in vivo biological activity, the analog having a non-peptide bond instead of a peptide bond between an amino acid of the active site and an adjacent amino acid, and having the same binding site as the naturally occurring peptide, so that the analog is capable of acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of the non-peptide bond, failing to exhibit the in vivo activity of the naturally occurring peptide.