Bicyclopolyazamacrocyclophosphonic acid half esters
US5750660A · kind A · utility
19Cited by
27References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1996 |
| Grant date | May 12, 1998 |
| Priority date | — |
| Expiry date | Jul 15, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.