Oligonucleotide analogs with terminal 3'-3' or 5'-5' internucleotide linkages

US5750669A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hannelore Rösch · Erbach, DE
• Anja Frohlich · Illerkirchberg, DE
• Jose Flavio Ramalho-Ortigao · Ulm, DE
• Matthias Montenarh · Senden, DE
• Hartmut Seliger · Neu-Ulm, DE

Key dates

• Filing date: Aug 1, 1994
• Grant date: May 12, 1998
• Expiry date: Aug 1, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R15/186
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Therapeutically utilizable oligonucleotides of the formulae I and II have been obtained by introduction of terminal 3'--3' and 5'--5' linkages. These compounds are stable to nucleases and suppress the biological function of nucleic acids.