Process for the preparation of arylmalonates

US5750766A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Guenter Krummel · Vendersheim, DE
• Marcus Knell · Ingelheim am Rhein, DE

Key dates

• Filing date: Mar 18, 1997
• Grant date: May 12, 1998
• Expiry date: Mar 18, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An effective and efficient process for the preparation of dialkyl arylmalonates of formula I, ##STR1## (ring A and R are defined in the specification). In this process, an arylmethylhalide of formula II ##STR2## is treated with magnesium in an inert solvent, the resulting Grignard reagent is treated with a dialkyl carbonate or an alkyl chloroformiate, and the resulting reaction mixture is treated with a base.