Method for effecting vasodilation with (1,5-inter) aryl prostaglandin derivatives
US5750784A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1997 |
| Grant date | May 12, 1998 |
| Priority date | — |
| Expiry date | Feb 18, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C405/0033
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of effecting vasodilation, comprising: PA1 administering to a warm blooded animal in need of such treatment, an effective amount of a (1,5-inter) aryl prostaglandin derivative represented by the Formula I ##STR1## wherein n is 0 or an integer of from 1 to 6, R is selected from the group of radicals represented by the formulae: EQU CO.sub.2 R', CONR'.sub.2, CH.sub.2 OR' and SO.sub.2 NR'.sub.2 ' wherein R' is hydrogen or a lower alkyl radical having from one to six carbon atoms; R" is hydrogen or an acyl radical having the formula (CO)R'" wherein R'" is a saturated or unsaturated acyclic hydrocarbon radical having from 1 to about 10 carbon atoms, or --(CH.sub.2).sub.m R"" wherein m is 0 or an integer of from 1 to 6 and R"" is an aliphatic ring having from 3 to 7 carbon atoms or an aryl group, e.g. phenyl, or a heteroaryl group, e.g. thienyl, furanyl or pyridyl, and preferably R'" is a lower alkyl group having from 1 to 6 carbon atoms; the hatched triangular segments represent alpha oriented bonds, the solid triangular segments represent beta oriented bonds and the wavy segments represent bonds that may be in either the cis or trans orientation.…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.