Process for preparing chiral tetralone
US5750794A · kind A · utility
6Cited by
11References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 29, 1996 |
| Grant date | May 12, 1998 |
| Priority date | — |
| Expiry date | May 29, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing the chiral (4S)-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is disclosed wherein racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone is asymmetrically reduced by contacting the racemic tetralone with an asymmetric reagent to produce a mixture of cis and trans alcohols, separating the cis from the trans alcohols, and oxidizing the (4S) enantiomer of the resulting cis and trans alcohols. Also disclosed are novel intermediates used in the synthesis of the above chiral tetralone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.