Use of paramagnetic compounds to measure temperature and pH in vivo
US5753207A · kind A · utility
4Cited by
7References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 19, 1996 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | Aug 19, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for measuring temperature and/or pH in vivo using paramagnetic compounds, e.g., lanthanide complexes, in conjunction with NMR has been developed. The chemical shift of the nuclear spin in these complexes can then be correlated to temperature. This non-invasive temperature measurement method is particularly useful in monitoring temperature of cancerous tissue during hyperthermic treatment to destroy the cancerous tissue or tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.