Lipid-coated condensed-phase microparticle composition
US5753261A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 17, 1995 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | May 17, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/586
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A microparticle composition for use in compound delivery, when the composition is exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, is disclosed. The composition includes a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.