Cationic lipid acid salt of 3betaN- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof
US5753262A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0055
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses a novel cationic lipid acid salt of 3.beta.N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol. This invention further discloses a transmembrane compatible body suitable for transfection of animals and animal cells with nucleotides such as DNA, RNA, and synthetic nucleotides. Such transmembrane compatible bodies arise from hydratable non-liposomal halogenated solvent-free lyophilate comprising 3.beta.N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol and DOPE. This invention yet further discloses a halogenated solvent-free aqueous solution, suitable for lyophilization into a preliposomal powder, wherein the solution comprises 3.beta.N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol wherein substantially all 3.beta.N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol is dissolved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.