Process for the preparation of (L)-2-chloropropionic acid and its salts using lipase from pseudomonas

US5753495A · kind A · utility

Assignee

• BASF SE

Inventors

• Wolfgang Ladner
• Hansjörg Rettenmaier · Grünstadt, DE
• Bernhard Zipperer · Dirmstein, DE
• Hanspeter Hansen

Key dates

• Filing date: Feb 15, 1996
• Grant date: May 19, 1998
• Expiry date: Feb 15, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/40
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.