Protein labelling
US5753520A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 6, 1995 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | Feb 6, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.