Peptide inhibitors of cellular adhesion
US5753617A · kind A · utility
42Cited by
4References
3Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 7, 1995 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | Mar 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel cyclic peptides of the selectin 54-63 sequence exhibit unexpected and desired properties. Specific points of cyclization or conformational restriction in conjunction with specific substitutions have been identified that not only unexpectedly enhance the biological activity of these compounds, but also significantly increase their resistance to enzymatic degradation. Formulae of the active compounds and representative examples of preferred peptides are presented herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.