Inhibitors of farnesyl-protein transferase
US5753650A · kind A · utility
0Cited by
9References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 6, 1996 |
| Grant date | May 19, 1998 |
| Priority date | — |
| Expiry date | Nov 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer, which compound has the structure; ##STR1## or a pharmaceutically acceptable salt or disulfide thereof and wherein the variables are as defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.