Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents

US5756065A · kind A · utility

Assignee

• THE DOW CHEMICAL COMPANY · US

Inventors

• David A. Wilson · Lake Jackson, US
• Joseph R. Garlich · Lake Jackson, US
• William A. Fordyce · Midland, US
• R. Keith Frank · Lake Jackson, US
• Jaime Simon · Angleton, US
• William F. Goeckler · Plainsboro, US
• Roberta C. Cheng · Midland, US
• William J. Kruper, Jr. · Sanford, US
• Kenneth McMillan · Lake Jackson, US

Key dates

• Filing date: Feb 15, 1995
• Grant date: May 26, 1998
• Expiry date: Feb 15, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/0482
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.