Oxygen activatable formulations for disinfection or sterilization
US5756090A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 1, 1995 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Jun 1, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/404
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are disclosed for producing air-activated, i.e., oxygen (O.sub.2) activated, disinfectant-sterilent solutions. Solutions containing a haloperoxidase (i.e., a halide:hydrogen peroxide (H.sub.2 O.sub.2) oxidoreductase, such as myeloperoxidase, eosinophil peroxidase or lactoperoxidase) plus a halide or combination of halides (i.e., chloride, bromide and/or iodide), an oxidase (i.e., a substrate: O.sub.2 oxidoreductase) capable of generating H.sub.2 O.sub.2, and a substrate specific for that oxidase, are separately prepared under aerobic conditions, but all of the component solutions are made anaerobic prior to final combination and mixing. The anaerobic formulations are dispensed into containers capable of maintaining the anaerobic condition (e.g., pressurized canisters). Dispensing the solution at the time of use exposes the formulation to air (i.e., O.sub.2) which activates its disinfectant-sterilent properties. O.sub.2 is the rate limiting component for oxidase generation of H.sub.2 O.sub.2. Under aerobic conditions the oxidase catalyzes the oxidation of its substrate and the reduction of O.sub.2 to generate H.sub.2 O.sub.2. In turn, H.sub.2 O.sub.2 serves …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.