Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
US5756122A · kind A · utility
20Cited by
12References
18Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1277
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved method for encapsulating high molecular weight nucleic acids in liposomes, which provides for high nucleic acid entrapment efficiencies, is provided. The resulting compositions provide enhanced in vitro and in vivo transfection and are useful, for example, in producing cell lines expressing a desired nucleic acid sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.