Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms

US5756450A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Lorenz Hahn · Siebnen, CH
• Birgit Hauer · Lahr (Eifel), DE
• Ulrich Posanski · Glückstadt, DE

Key dates

• Filing date: Nov 7, 1994
• Grant date: May 26, 1998
• Expiry date: Nov 7, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2054
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A combination of a pharmacologically active compound and a water soluble monoester of a saturated or unsaturated (C.sub.6-18) fatty acid and a polyol, especially a saccharide, particularly as a solid solution of the active compound in the monoester. The solid solution is especially suitable for substantially water insoluble active compounds, particularly such polypeptides, e.g. ciclosporins and is in all desirable weight ratios miscible with water. The invention also, in particular, provides pharmaceutical compositions comprising a cyclosporin as active ingredient together with a fatty acid saccharide monoester.