1,2,3,4-tetrahydroisoquinoline derivatives and pharmaceutical composition thereof
US5756516A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1996 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Dec 20, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to compounds of formula (I) ##STR1## wherein R.sup.1 is an optional substituent any position of phenyl ring and is selected from halogen, --NO.sub.2, --NH.sub.2, --OH and --O--CR.sub.1-6 alkyl; PA1 --CH.sub.2 R.sup.2 is a substituent at 1- or 3- position of 1,2,3,4-tetrahydroisoquinoline, wherein PA1 R.sup.2 is an azole group such as imidazole or triazole; and PA1 R.sup.3 is phenyl optionally substituted with one or more halogen, and pharmaceutical salts thereof. The compounds of formula (I) and salts thereof are useful as antifungal agents. The invention also relates to the antifungal pharmaceutical compositions containing the compounds of formula (I), the methods of treating fungal infections using the compounds of formula (I) and the process for preparing the compounds of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.