Method of making 2'-O-alkyl pyrimidine ribonucleosides
US5756707A · kind A · utility
2Cited by
4References
20Claims
0Family size
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Key dates
| Filing date | Dec 13, 1994 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Dec 13, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Method for production of 2'-O-derivatized uridine and cytosine RNA synthons comprising derivatizing the 2'-hydroxyl group of a partially protected cytosine ribonucleoside to preferentially produce a partially protected 2'-O-derivatized nucleoside, which is then either (1) reacted at the 3'-hydroxyl group to produce a 2'-O-derivatized cytosine RNA synthon, or (2) reacted with a hydroxide source to produce a uridine nucleobase by deamination, thereby producing a partially protected 2'-O-derivatized uridine ribonucleoside which can be reacted at its 3'-hydroxyl group to produce a uridine RNA synthon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.