Process for preparing 1,1'-1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecan e
US5756728A · kind A · utility
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5Claims
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Key dates
| Filing date | Dec 30, 1996 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Dec 30, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for preparing 1,1'-1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-1,4-phenylenebis-(methylene)!-bis-1,4,8,11-tetraazacyclotetradecane.
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