Continuous processes for the hydrolysis of cyanopyridines under substantially adiabatic conditions
US5756750A · kind A · utility
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4References
40Claims
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Key dates
| Filing date | Feb 7, 1997 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Feb 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/81
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described are preferred processes for hydrolyzing substituted and unsubstituted cyanopyridines in the presence of a base and under substantially adiabatic conditions to produce pyridine substituted amides and/or pyridine substituted carboxylic acids. Preferred processes can be conducted in a variety of continuous reactors including cascades of reaction vessels, loop reactors or flow tube reactors. More preferred are the efficient and advantageous preparations of nicotinamide and niacin, which serve as important members of the B-vitamin complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.