Process for preparing intermediates for the synthesis of antifungal agents
US5756830A · kind A · utility
0Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1996 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Dec 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for producing a crystalline chiral hydroxy ester of the formula: ##STR1## is disclosed. The process comprises reacting a diol of the formula: ##STR2## with an effective amount of isobutryic anhydride and an effective amount of a lipase enzyme in an effective amount of acetonitrile, said reaction being conducted at a low temperature, and wherein X.sup.1 and X.sup.2 are each independently selected from F or Cl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.