Process for grafting a substituted difluoromethyl group onto a compound containing an electrophilic functional group
US5756849A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 22, 1996 |
| Grant date | May 26, 1998 |
| Priority date | — |
| Expiry date | Mar 22, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process and a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function, characterized in that it comprises: PA1 a) a fluorocarboxylic acid of formula Ew--CF.sub.2 --COOH where Ew represents an electron-withdrawing atom or group, at least partially salified with an organic or inorganic cation, and PA1 b) a polar aprotic solvent; and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.