Metal complexes of dendrimeric macromolecules, diagnostics agents that contain the latter as well as process for the production of the complexes and agents

US5759518A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE

Key dates

• Filing date: Oct 3, 1996
• Grant date: Jun 2, 1998
• Expiry date: Oct 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G83/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand of formula I EQU A--(X).sub.b (I) in which A, X and b have different meanings, agents that contain these compounds as well as the use of the latter in diagnosis. The invention further relates to a process for the production of the complexes and agents.