Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5759542A · kind A · utility
215Cited by
2References
11Claims
0Family size
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Inventor
Key dates
| Filing date | Aug 5, 1994 |
| Grant date | Jun 2, 1998 |
| Priority date | — |
| Expiry date | Aug 5, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A fusion drug including an isolated portion of the A-chain of a urokinase-type plasminogen activator linked to a drug, wherein the A-chain portion binds stably to an outer membrane of a platelet. The T.sub.1/2 of the fusion drug in plasma is thereby increased to about 4 to 5 days, and the fusion drug is automatically targeted to forming thrombi and sites of vascular injury. The fusion drug can thus be used to treat cardiovascular diseases, e.g., as adjunctive therapy to inhibit reocclusions in a patient after thrombolytic therapy or angioplasty.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.