Peptides useful for altering .alpha..sub.v .beta..sub.3 -mediated binding
US5759996A · kind A · utility
16Cited by
9References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1995 |
| Grant date | Jun 2, 1998 |
| Priority date | — |
| Expiry date | Apr 12, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides Arg-Gly-Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also provides methods of using the Arg-Gly-Asp peptides to alter .alpha..sub.v .beta..sub.3 integrin receptor-mediated binding of a cell such as an osteoclast, endothelial cell or smooth muscle cell to a matrix. The invention further provides methods for ameliorating the severity of a pathology characterized, in part, by an undesirable level of bone resorption, angiogenesis or restenosis in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.