4-aminoquinazoline EGFR Inhibitors

US5760041A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Allan Wissner · Monsey, US
• Bernard D. Johnson · Stony Point, US
• Middleton B. Floyd, Jr. · Suffern, US
• Douglas B. Kitchen · Schenectady, US

Key dates

• Filing date: Jan 21, 1997
• Grant date: Jun 2, 1998
• Expiry date: Jan 21, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted; PA1 R and R.sub.1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; PA1 R.sub.2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; PA1 Y is a radical selected from the group consisting of ##STR2## R.sub.3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; PA1 n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R.sub.3 of Y may be the same or different which are useful as antineoplastic agents.