Process for retarding hair loss and for inducing and stimulating its growth

US5760043A · kind A · utility

Assignee

• L'Oreal · FR

Inventors

• Didier Dufetel · Chelles, FR
• Francoise Estradier · Paris, FR
• Quintino Gaetani · Sevran, FR
• Michel Hocquaux · Paris, FR

Key dates

• Filing date: Dec 18, 1996
• Grant date: Jun 2, 1998
• Expiry date: Dec 18, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/95
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions intended for use for retarding hair loss and for inducing and stimulating its growth, containing 2-aminopyrimidine 3-oxide derivatives, and new compounds derived from 2-aminopyrimidine 3-oxide. Composition for retarding hair loss and for inducing and stimulating its growth, containing at least one compound of formula: ##STR1## where R denotes H, alkyl or a ring of formula: ##STR2## X denotes ##STR3## with: R.sub.1 and R.sub.3 denote H, alkyl, optionally substituted, alkenyl, cycloalkyl, aralkyl or aryl of formula: ##STR4## where R.sub.9 and R.sub.10 denote H, alkyl, hydroxyl, alkoxy or halogen; or form a heterocycle with the nitrogen; PA1 R.sub.3 denotes alkyl, alkenyl, cycloalkyl, aralkyl, optionally substituted phenyl; PA1 R.sub.4 is identical to R.sub.3 ; PA1 Y denotes O or --OSO.sub.3.sup..crclbar. ; PA1 R' denotes H or ##STR5## R.sub.5 and R.sub.6 are alkyl; R.sub.7 and R.sub.8 denote H or alkyl; PA1 or its physiologically acceptable addition salts with acids.