Method of treatment for decreasing mortality resulting from congestive heart failure

US5760069A · kind A · utility

Assignee

• Boehringer Mannheim Pharmaceuticals Corporation-SmithKline Beecham Corporation Limited Partnership #1 · US

Inventors

• Mary Ann Lukas-Laskey · Rosemont, US
• Robert Ruffolo · Spring City, US
• Neil Howard Shusterman · Lansdowne, US
• Gisbert Sponer · Hemsbach, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jun 2, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treatment using a compound of Formula I: ##STR1## wherein: R.sub.1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; PA1 R.sub.2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; PA1 R.sub.3 is hydrogen or lower alkyl of up to 6 carbon atoms; PA1 R.sub.4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; PA1 X is a valency bond, --CH.sub.2, oxygen or sulfur; PA1 Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; PA1 R.sub.5 and R.sub.6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a --CONH.sub.2 -- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or PA1 R.sub.5 and R.sub.6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, alone or in conjunction with one or more other therapeutic agents, said agents being selected from…