Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy
US5760072A · kind A · utility
8Cited by
0References
5Claims
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Key dates
| Filing date | Sep 30, 1996 |
| Grant date | Jun 2, 1998 |
| Priority date | — |
| Expiry date | Sep 30, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.