Process for preparing optically active metallocenyl-phosphines
US5760264A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 9, 1997 |
| Grant date | Jun 2, 1998 |
| Priority date | — |
| Expiry date | Jul 9, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F17/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a novel method of producing optically active metallocenyl phosphines of the general formula shown In the formula (Ia) (Ib), M represents iron, ruthenium or nickel; R.sup.1 and R.sup.1' both represent C.sub.1 -C.sub.4 alkyl groups; R.sup.2 and R.sup.3 each represent independently of each other either hydrogen or a C.sub.1 -C.sub.4 alkyl group, or, together with the nitrogen atom, form a five- or six member saturated heterocyclic ring which may optionally contain further heteroatoms; R.sup.4 and R.sup.5 each represent independently of each other a C.sub.1 -C.sub.4 alkyl group (for example) or an aryl group which is optionally substituted with one or more methyl or methoxy groups or with one or more fluorine atoms. These are obtained from acyl- or 1,1'-diacylmetallocenes by enantioselective reduction with borane in the presence of optically active oxazoborolidines, esterification of the metallocenyl alkanols thus obtained, nucleophilic substitution of the ester group with a secondary amine, lithiation and reaction with a phosphine halide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.