Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
US5762918A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 5, 1994 |
| Grant date | Jun 9, 1998 |
| Priority date | — |
| Expiry date | Dec 5, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably linked by a selectively-hydrolyzable bond, such as an acid-labile bond or enzyme-sensitive bond. The first component, a polyanionic polymer, and preferably, a polysulphated polymer such as a heparin-derivative, specifically directs the conjugate to vascular endothelial cells. The second component is a selected agent, such as a steroid, which exerts a specific effect on the target cell following its release. In particular, the present invention provides novel conjugated angiogenesis inhibitors, for use in the treatment of pathogenic conditions including cancer, arthritis, and diabetic blindness. An inhibitor comprising a heparin derivative and the anti-angiogenic steroid, cortisol, is herein shown to be markedly acid-labile, to suppress DNA synthesis and cell migration in human umbilical vein endothelial cells, to retard or abolish (depending pending on the route of injection) the vascularization of sponges in vivo and to retard lung tumor growth in mice by 65%. No adverse effects of the conjug…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.