Thymus tolerance in primates
US5762927A · kind A · utility
3Cited by
1References
4Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 11, 1997 |
| Grant date | Jun 9, 1998 |
| Priority date | — |
| Expiry date | Apr 11, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.