Peralkylated oligopeptide mixtures

US5763193A · kind A · utility

Assignee

• Torrey Pines Institute for Molecular Studies · US

Inventors

• Richard A. Houghten · Del Mar, US
• John M. Ostresh · Encinitas, US
• Sylvie E. Blondelle · Village of La Jolla, US

Key dates

• Filing date: Dec 22, 1995
• Grant date: Jun 9, 1998
• Expiry date: Dec 22, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/18
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides.