Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones

US5763474A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• David R. Herbst · Wayne, US
• Madelene M. Antane · Lawrenceville, US
• Geraldine Ruth McFarlane · Monmouth Junction, US
• Eric Gould Gundersen · Royersford, US
• Bradford H. Hirth · Framingham, US
• Dominick Anthony Quagliato · Edison, US
• Russell Graceffa · Hampton, US
• John A. Butera · Clarksburg, US

Key dates

• Filing date: Jul 7, 1997
• Grant date: Jun 9, 1998
• Expiry date: Jul 7, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds of the formula: ##STR1## wherein R.sub.1 is straight chain alkyl, branched chain alkyl cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R.sub.2 and R.sub.3 are, independently, hydrogen or an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkoxycarbonyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is a substituted phenyl group of the following formula: ##STR2## wherein R.sub.4 and R.sub.5 are, independently, cyano, nitro, amino, alkyl, perfluoroalkyl, fluoroalkyl, alkoxy, perfluoroalkoxy, fluoroalkoxy, amino, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylsulfonamido, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarboxamido, arylcarboxamido, alkylsulfonyl, perfluoroalkylsulfonyl, arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen, with the proviso that R.sub.4 and R.sub.5 cannot both be hydrogen; or a pharmaceutically acceptable salt thereof, relaxes smooth muscles.