Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof
US5763631A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 20, 1996 |
| Grant date | Jun 9, 1998 |
| Priority date | — |
| Expiry date | Jun 20, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cis-epoxide compounds of formula (I-3) and pharmaceutically acceptable salts, hydrates and solvates thereof: ##STR1## wherein: R.sup.1 is a cycloalkyl, or arly-substituted lower alkyl group; PA1 K and J are independently a group having the formula of ##STR2## wherein R.sup.18 is a lower alkyl group optionally substituted with an aryl radical; X is O, NH, or N--CH.sub.3 ; and R.sup.19 is an aromatic hetercyclic sysstem containing a nitrogen atom in its ring, or a lower alkyl group optionally substituted with an aryl radical, or a hydrogen; PA1 G is an amino acid which is linked to K-- and ##STR3## by peptide bonds in formula (I-3); Q is an amino acid which is linked to by peptide bonds in formula (I-3), or a group having the formula of wherein R.sup.20 is a lower alkyl group optionally substituted with an aromatic radical; and Y is CH.sub.2, O or NH; and PA1 r is 0 or 1, except that Q is a group having the formula of r is 0.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.