Transgenic non-human mammals producing BSSL variants

US5763739A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Lars Gustav Blackberg · Wasserburg am Inn, DE
• Michael Edlund · Wasserburg am Inn, DE
• Stig Lennart Hansson · Wasserburg am Inn, DE
• Olle Hernell · Umeå, SE
• Lennart Gustav Lundberg · Lindome, SE
• Mats Stromqvist · Wasserburg am Inn, DE
• Jan Törnell · Mölndal, SE

Key dates

• Filing date: May 19, 1995
• Grant date: Jun 9, 1998
• Expiry date: May 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/85
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel polypeptides which are variants of Bile Salt-Stimulated Lipase (BSSL; EC 3.1.1.1). It also relates to DNA molecules encoding the said polypeptides, and to subproducts comprising the said DNA molecules. The invention further relates to processes for producing the said BSSL variants and for producing transgenic non-human mammals capable of expressing the BSSL variants. Furthermore the invention relates to such transgenic animals as well as to infant formulas comprising milk from such transgenic animals. The invention also relates to pharmaceutical compositions comprising the said polypeptides; and the use of the said polypeptides and DNA molecules for the manufacture of medicaments.