Water-soluble carboxypolysaccharide-magnetic iron oxide complex having a small particle diameter

US5766572A · kind A · utility

Assignee

• Meito Sangyo Co., Ltd. · JP

Inventors

• Masakatsu Hasegawa · Nagoya, JP
• Yoshio Ito · Fujinomiya, JP
• Hisato Yamada · Toyota, JP
• Hideo Nagae · Kasugai, JP
• Nahoko Tozawa · Seto, JP
• Yukari Hino · Nagoya, JP
• Kyoji Kito · Nagoya, JP
• Shusaburo Hokukoku · Kani, JP
• Rudiger Lawaczeck · Berlin, DE
• Wolfgang Ebert · Krefeld, DE
• Detlef Pfefferer · Berlin, DE
• Susanne Wagner · Mittenwalde, DE
• Mayk Kresse · Berlin, DE

Key dates

• Filing date: Feb 6, 1995
• Grant date: Jun 16, 1998
• Expiry date: Feb 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A water-soluble carboxypolysaccharide-magnetic iron oxide complex of small particle diameter composed of a water-soluble carboxypolysaccharide and a magnetic iron oxide having a core diameter ranging from about 2 to about 7 nm, wherein the total diameter ranges from about 10 to about 50 nm, the ratio of the total diameter to the core diameter is about 15 or less, and the T.sub.2 -relaxivity ranges from about 10 to about 150 (mM.sec).sup.-1. Said complex has low toxicity and small side effects and is useful in the fields of medical treatment, biology and engineering as an iron-supplementing agent, an X-ray contrast medium, an MRI contrast medium, a reagent for blood flow rate measurement, a carrier for drug administration, etc.