Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5766581A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1995 |
| Grant date | Jun 16, 1998 |
| Priority date | — |
| Expiry date | Mar 30, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.