Patent · US Expired

Method of treatment for cystic fibrosis and peptides for same

US5767084A · kind A · utility

0Cited by
12References
3Claims
0Family size

Assignee

Inventors

Key dates

Filing dateOct 6, 1995
Grant dateJun 16, 1998
Priority date—
Expiry dateOct 6, 2015

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K38/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Peptides derived from mutant CFTR protein which inhibit intracellular degradation and/or retention of mutant CFTR proteins are disclosed. A method of inhibiting intracellular degradation and/or retention of mutant CFTR protein by administering peptides having an amino acid sequence corresponding to mutant CFTR amino acid sequences is also disclosed. Further, a method of preventing cellular retention and degradation of an otherwise membrane bound protein by competitively inhibiting intracellular degradation (proteolysis) and retention which would otherwise retain or degrade synthesized mutant proteins prior to arrival of the protein at the cell surface is disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.