Nitric oxide sequestrant
US5767103A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 19, 1995 |
| Grant date | Jun 16, 1998 |
| Priority date | — |
| Expiry date | Apr 19, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/714
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes a method of sequestering nitric oxide from the bloodstream, endothelium or tissues of mammals by administering a cobalamin to such mammals. A method of treating diseases characterized by elevated nitric oxide levels in the bloodstream, endothelium or tissues is further provided. In particular, a method of treating sepsis by administering a therapeutic dose of hydroxocobalamin is described by the present invention. A method of alleviating systemic hypotension in a septic patient is further described by this invention. A pharmaceutical composition comprising a cobalamin in a concentration ranging from 0.5 to 50 mg composition/Kg body weight for mammals and is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.