1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls

US5767136A · kind A · utility

Assignee

• Recordati S.A. Chemical and Pharmaceutical Company · CH

Inventors

• Abraham Sartani · Arese, IT
• Amedeo Leonardi · Milano, IT
• Rodolfo Testa · Milano, IT

Key dates

• Filing date: May 10, 1996
• Grant date: Jun 16, 1998
• Expiry date: May 10, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject invention provides methods for preventing, retarding, or reducing atherosclerotic lesions or atherosclerotic degradation of aterial walls or treating atherosclerosis comprising administering to a mammal in need of such prevention, retardation, reduction or treatment at least one compound having the formula I: ##STR1## wherein: Ph is phenyl, PA1 Ar is: 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, PA1 A is a branched chain alkylene radical having from 2 to 6 carbon atoms, PA1 R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, PA1 R.sub.1 is hydrogen, hydroxy, or an alkyl radical having from 1 to 4 carbon atoms, PA1 R.sub.2 is hydrogen, or methyl; or an enantiomer of a compound having formula I; a hydrated compound having formula I; a solvated compound having formula I; a pharmaceutically acceptable acid addition salt, or any of the foregoing.