Taxoid derivative and method of producing thereof
US5767297A · kind A · utility
19Cited by
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21Claims
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Key dates
| Filing date | Jun 3, 1997 |
| Grant date | Jun 16, 1998 |
| Priority date | — |
| Expiry date | Jun 3, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A taxoid derivative wherein sugar is combined with any one of paclitaxel, docetaxel and 10-deacetyl-bacatin III via a spacer. A method of producing the taxoid derivative comprises protecting hydroxyl groups at specific position of paclitaxel or docetaxel by protective compound followed by reacting with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl and detriethylsilyl reactions. A method of producing the taxoid derivative comprises reacting paclitaxel or docetaxel with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.