Contrast agents

US5767299A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Jo Klaveness · Oslo, NO
• Per Strande · Oslo, NO

Key dates

• Filing date: Sep 18, 1995
• Grant date: Jun 16, 1998
• Expiry date: Sep 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from: (i) saturated or unsaturated fatty acyl groups, preferably having from 14 to 24 carbon atoms, more preferably of a type found in nature; or PA0 (ii) groups of formula (II): ##STR2## wherein R.sup.4 and R.sup.5 are independently selected from hydrogen atoms, C.sub.1-4 alkyl groups and aryl groups, preferably C.sub.6-10 aryl groups; n represents the integers 0 or 1; A represents either a chemical bond or a straight or branched C.sub.1-6 alkylene chain and R.sup.6 is a triiodinated phenyl group which may also carry other substituents. The invention also relates to X-ray contrast media containing these compounds, as well as methods of enhancing X-ray images of a human subject wherein the contrast media are administered to the subject prior to imaging.