Patent · US Expired

Processes for preparing L!- or D!-homoalanin-4-yl-(methyl)phosphinic acid and salts thereof by racemate resolution

US5767309A · kind A · utility

14Cited by

7References

11Claims

0Family size

Assignee

Hoechst Schering Agrevo GmbH · DE

Inventors

Harald Knorr · Frankfurt am Main, DE
Gunter Schlegel · Liederbach, DE
Herbert Stark · Kelkheim, DE

Key dates

Filing date	Mar 2, 1995
Grant date	Jun 16, 1998
Priority date	—
Expiry date	Mar 2, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/301
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Processes for preparing L!- or D!-homoalanin-4-yl-(methyl)phosphinic acid and salts thereof by racemate resolution The title compounds are obtained by racemate resolution of D,L-homoalanin-4-yl (methyl)phosphinic acid via precipitation of one of the diastereomeric salts using chiral bases such as quinine or cinchonine. It is possible to increase the yield of desired enantiomer by transformed racemate resolution when the precipitation of the diastereomeric salt takes place with the racemization of the undesired enantiomer in the presence of (hetero)aromatic aldehydes. The racemization method is also suitable for structurally different optically active amino acids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.